Biomarker for treating cancer patients

摘要

The present invention concerns biomarkers and use thereof for determining whether a subject is or is not susceptible to developing a prophylactic or therapeutic immune response after such treatment.

主权项

1. A method of treating a cancer patient, the method comprising administering an effective amount of an immunogenic composition comprising a vaccinia virus vector comprising a heterologous nucleotide sequence encoding MUC-1 to a cancer patient identified as having an interleukin 10 (IL-10)/interferon γ (IFNγ) ratio below 5 prior to administration of the immunogenic composition, wherein the IL-10/IFNγ ratio is calculated by measuring the levels of IL-10 and IFNγ in a biological sample from the patient prior to administration of the immunogenic composition and determining the IL-10/IFNγ ratio based on the measured levels of IL-10 and IFNγ.