| 主权项 |
1. A compound of structural formula I: including tautomers or a pharmaceutically acceptable salt, an individual enantiomer or a diastereomer thereof wherein: A represents hydrogen, or C1-6 alkyl, said alkyl optionally substituted with 1 to 3 groups independently selected from halo, OH, or Oalkyl; X represents hydrogen, OH, halo, OC1-6 alkyl, NR2R3, or (CH2)nC6-10 aryl, said alkyl and said aryl optionally substituted with 1 to 3 groups of Ra; R1 represents C6-10 aryl or (CH2)nheterocyclyl, said aryl and heterocyclyl substituted with 1 to 3 groups of Ra; R2 and R3 independently represent H, OH, C1-6 alkyl, N(CH3)2, (CH2)n heterocyclyl, or (CH2)nC6-10 aryl, said aryl and heterocyclyl optionally substituted with 1 to 3 groups of Ra; or R2 and R3 together with the nitrogen atom to which they are attached form a 5-10 membered ring that is optionally substituted with 1 to 3 groups independently selected from halo, OH, C2-6 alkenyl, (CH2)nheterocyclyl or (CH2)nC6-10 aryl; each Ra independently represents C1-6 alkyl, halogen, C2-4alkynyl, (CH2)nCF3, OCHF2, OCF3, C3-6 cycloalkyl, O(CH2)nC3-6 cycloalkyl, NR2C(O)R2, C(O)N(R2)2, C(R2)2OR2, C(O)R2, NO2, CN, N(R2)2, (CH2)nC(O)OR2, SO2R2, NHSO2R2, OC1-6 alkyl, (CH2)n heterocyclyl, NH(CH2)nheterocyclyl, (CH2)nC6-10 aryl, O(CH2)nC6-10 aryl, or O(CH2)n heterocyclyl, said alkyl, alkynyl, cycloalkyl, heterocyclyl and aryl optionally substituted with 1 to 3 groups of Rb; each Rb independently represents C1-6 alkyl, OC1-6 alkyl, halogen, CHF2, OCHF2, —O—, N(R2)2, CH2OH, S(O)2NR2R3, (CH2)nC6-10 aryl, (CH2)n heterocyclyl, C(O)(CH2)n heterocyclyl, NH(CH2)nheterocyclyl, C(O)NHC3-6cycloalkyl, OR2, C3-6cycloalkyl, (CH2)nCF3, or CN, said heterocyclyl optionally substituted with 1 or more of C1-6 alkyl; and n represents 0 to 5. |
