Ocular therapy using glucocorticoid derivatives selectively penetrating posterior segment tissues

摘要

Ophthalmically therapeutic materials, such as liquid-containing compositions and polymeric drug delivery systems, include a therapeutic component that includes an Glucocorticoid Derivative which, upon delivery to the posterior segment of a mammalian eye, does not significantly diffuse to the anterior segment of said eye. Methods of making and using the present materials are also described.

主权项

1. A method of treating macular edema of a mammalian eye comprising periocular administration of a composition comprising a therapeutically effective amount of hyaluronic acid and a glucocorticoid derivative comprising an acyl group linked to C17 via an ester linkage.