Synergistic antiviral compositions comprising a viral attachment inhibitor, an integration inhibitor, and a proviral transcription inhibitor, and their use

摘要

Compounds, compositions and methods for the treatment of HIV/HSP/HPV, in particular, compositions and methods for a 3 part combination therapy for HIV/HSV/HPV, comprising a viral attachment inhibitor, a viral sequence integration inhibitor, and a proviral transcription inhibitor. The therapy is advantageous for the treatment of HIV infection, and is also effective for HSV and HPV infection. Also disclosed are novel viral attachment inhibitors and methods of use.

主权项

1. A method of treating HIV infection in an individual comprising the administration of effective amounts of a viral attachment inhibitor, a viral sequence integration inhibitor, and a proviral transcription inhibitor, in synergistic amounts, to an individual in need of treatment,
wherein the triterpenoid saponin or derivative thereof is selected from the group consisting of arganine C (Rev. 1), Tieghemelin (Gen.1), acetylated arganine C or acetylated Tieghemelin, wherein the viral sequence integration inhibitor is lithospermic acid (M522) or lithospermic acid B (M532), and wherein the proviral transcription inhibitor is a nontoxic water-soluble derivative of NDGA selected from the group consisting of M4N, G4N, P4N and Mal.4.