| 发明名称 | Methotrexate composition | ||
| 摘要 | A Methotrexate composition for oral administration is provided comprising a pharmaceutically acceptable salt of Methotrexate and an aqueous carrier agent. The Methotrexate salt is substantially or completely soluble in the aqueous carrier agent, forming an aqueous solution. There is also provided a method of manufacturing a Methotrexate composition for oral administration, comprising mixing a pharmaceutically acceptable salt of Methotrexate with an aqueous carrier agent until the Methotrexate salt is substantially or completely soluble in the carrier agent to form an aqueous solution. | ||
| 申请公布号 | US9259427(B2) | 申请公布日期 | 2016.02.16 |
| 申请号 | US201313733031 | 申请日期 | 2013.01.02 |
| 申请人 | Rosemont Pharmaceuticals LTD | 发明人 | Tierney Carl;Powell Stacey;Braybrooke Peter;Jones Geraint |
| 分类号 | A61K31/519;A61K47/02;A61K47/12;A61K47/14;A61K9/00 | 主分类号 | A61K31/519 |
| 代理机构 | GableGotwals | 代理人 | GableGotwals |
| 主权项 | 1. A Methotrexate composition for oral administration, said composition consisting of a pharmaceutically acceptable salt of Methotrexate, purified water, one or more buffer agents to adjust the pH of the composition, wherein the pH of the composition is 6.25+/−0.15 and the one or more buffer agents have a strength between 2 to 20 millimolar, and one or more agents selected from the group consisting of preserving agents, flavouring compounds, and sweetening agents. | ||
| 地址 | Leeds GB | ||