３−ピリジル−１−ヒドロキシエチリデン−１，１−ビスホスホン酸ナトリウムを２．５水和物又は１水和物として選択的に結晶化する方法

摘要

The present invention discloses 3-pyridyl-1-hydroxyethylidene-1,1-bisphosphonic acid sodium hemipentahydrate and monohydrate, methods of preparing the hemipentahydrate or monohydrate through control of the nucleation temperature and rate of crystallization and pharmaceutical compositions containing one or both of the hydrate forms.