| 主权项 |
1. A purified binding molecule capable of binding L1CAM
(i) comprising the following six CDR sequences RASQDISNYLN (SEQ ID No: 1), YTSRLHS (SEQ ID No: 2), QQGNTLPWT (SEQ ID No: 3), RYWML (SEQ ID No: 4), EINPRNDRTNYNEKFKT (SEQ ID No: 5), and GGGYAMDY (SEQ ID No: 6),
or (ii) which is capable of binding to the same L1CAM epitope recognized by the monoclonal antibody 9.3, produced by the hybridoma cell deposited under DSMZ ACC2841, or (iii) comprising the following six CDR sequences QDISNY (SEQ ID No: 7), YTS, QQGNTLPWT (SEQ ID No: 8), GYTFTRYW (SEQ ID No: 9), INPRNDRT (SEQ ID No: 10), and ALGGGYAMDY (SEQ ID No: 11),
wherein the purified binding molecule capable of binding L1CAM is selected from the group consisting of single chain antibody (scFv), a multimer of scFv, a diabody, a triabody, a tetrabody, an antigen-binding fragment of a monoclonal antibody, a Fab, a tandab, a flexibody, a bispecific antibody, and a chimeric antibody. |
