| 发明名称 | Peptide sequence design and use thereof for peptide-mediated siRNA delivery | ||
| 摘要 | The invention provides, in one aspect, peptides and a complex comprising one of the peptides and a cargo molecule, wherein the peptide and the cargo molecule are coupled by non-covalently. The peptides of the invention were found to facilitate the delivery of siRNA molecules into cells and to function in siRNA mediated silencing of cellular targets. | ||
| 申请公布号 | US9259483(B2) | 申请公布日期 | 2016.02.16 |
| 申请号 | US201214359873 | 申请日期 | 2012.11.23 |
| 申请人 | Positec Power Tools (Suzhou) Co Ltd | 发明人 | Chen Pu;Jafari Mousa;Xu Wen;Chen Baoling;Pan Ran;Karunaratne Nedra |
| 分类号 | A61K48/00;C07H21/02;C07H21/04;A61K47/48;A61K31/713;C12N15/87;C07K14/47;C12N15/11;C07K19/00;C12N15/113;A61K9/00;A61K9/08;A61K38/00 | 主分类号 | A61K48/00 |
| 代理机构 | Dunlap Codding, P.C. | 代理人 | Dunlap Codding, P.C. |
| 主权项 | 1. A complex comprising a peptide having the amino acid sequence according to any one of SEQ ID NOs: 12 to 21, 28 to 33, and 44 to 46 and a cargo molecule. | ||
| 地址 | Jiangsu Province CN | ||