Intravascular sensing method and system

摘要

Methods and systems for calculating a corrected Fractional Flow Reserve. Methods include delivering a pressure sensing device including a pressure sensor to a location in an artery having a stenosis, positioning the pressure sensor distal to the stenosis, measuring the distal pressure, measuring the proximal pressure, and calculating a corrected Fractional Flow Reserve using the measured proximal and distal pressures and applying a correction factor or correction equation. The correction factor or correction equation corrects for changes in the measured distal pressure caused by a presence of the pressure sensing device. A data set of correction factors or correction equations may be stored in a memory component of the system. The corrected Fractional Flow reserve may approximate the Fractional Flow Reserve that would be obtained if a different sized device was used to measure the distal pressure, such as a pressure sensing guidewire having a 0.014 inch outer diameter.

主权项

1. A method of calculating a corrected Fractional Flow Reserve comprising:
delivering a pressure sensing device to a location in a blood vessel, the location having a stenosis, the pressure sensing device having a cross-sectional area in a portion of the device adapted to cross the stenosis during measurement of a pressure distal to the stenosis; positioning the pressure sensor distal to the stenosis; measuring the pressure distal to the stenosis while the pressure sensor is positioned distal to the stenosis; measuring a pressure proximal to the stenosis; and calculating with a processor the corrected Fractional Flow Reserve using the measured proximal and distal pressures and applying a correction factor or correction equation that is based on the cross-sectional area of the portion of the pressure sensing device adapted to cross the stenosis during measurement of the distal pressure and is based on a different cross-sectional area of a portion of a different pressure sensing device adapted to cross the stenosis during measurement of the pressure distal to the stenosis, wherein the correction factor or correction equation corrects for changes in the measured distal pressure caused by a presence of the pressure sending device having the cross-sectional area different from the cross-sectional area of the different pressure sensing device to produce the corrected Fractional Flow Reserve, wherein the corrected Fractional Flow Reserve approximates a Fractional Flow Reserve that would have been obtained if the distal pressure was measured using the different device.