| 发明名称 | Glycopyrrolate salts | ||
| 摘要 | Salts of glycopyrrolate, including solid forms and formulations such as topicals thereof, are disclosed. Methods of making glycopyrrolate salts, including formulations such as topicals thereof, and methods of treating hyperhidrosis with salts of glycopyrrolate, and formulations such as topicals thereof, are disclosed. | ||
| 申请公布号 | US9259414(B2) | 申请公布日期 | 2016.02.16 |
| 申请号 | US201514643553 | 申请日期 | 2015.03.10 |
| 申请人 | Dermira, Inc. | 发明人 | Statler John Allan;Shaw Anthony Adrian;Imbert Delphine Caroline;Nelson Jennifer Leigh;Andres Patricia;McQueen Lisa Lynn;Boerrigter Stephan Xander Mattheus;Selbo Jon Gordon;Andres Mark Christopher |
| 分类号 | A61K31/40;C07D207/12;C07C309/30;A61L15/24;A61L15/44;A61K9/00;A61K9/14;A61K31/10;A61K9/08 | 主分类号 | A61K31/40 |
| 代理机构 | Arnold & Porter LLP | 代理人 | Arnold & Porter LLP |
| 主权项 | 1. A method of treating hyperhidrosis comprising topically administering a therapeutically effective amount of a pharmaceutically acceptable solution of glycopyrrolate tosylate comprising a racemic mixture of (R)-3-((S)-2-cyclopentyl-2-hydroxy-2-phenylacetoxy)-1,1-dimethylpyrrolidinium 4-methylbenzenesulfonate and (S)-3-((R)-2-cyclopentyl-2-hydroxy-2-phenylacetoxy)-1,1-dimethylpyrrolidinium 4-methylbenzenesulfonate or solvate thereof to the skin of a mammal, wherein the pH of said pharmaceutically acceptable solution is between 3.5 and 5.5 at 25° C. | ||
| 地址 | Menlo Park CA US | ||