System and method for measuring an analyte in a sample and calculating hematocrit-insensitive glucose concentrations

摘要

Described are methods and systems to apply a plurality of test voltages to the test strip and measure a current transient output resulting from an electrochemical reaction in a test chamber of the test strip so that a glucose concentration can be determined that is simpler, less error prone and provides the unexpected advantage of being insensitive to hematocrits in the blood sample.

主权项

1. A method of determining blood glucose concentration with a glucose measurement system that includes a test strip and test meter, the test meter having a microcontroller configured to apply a plurality of test voltages to the test strip and measure a current transient output resulting from an electrochemical reaction in a test chamber of the test strip, the method comprising:
initiating a test sequence after deposition of a sample; transforming glucose in the sample from one form to a different form; switching a first voltage to a second voltage different than the first voltage; changing the second voltage to a third voltage different from the second voltage; measuring a first current output of a current transient from the electrodes at least at any point during and after the switching from the first voltage to the second voltage; measuring a second current output of the current transient at least at any point during and after the third voltage is maintained in the test chamber; and calculating a blood glucose concentration based on a logarithm of a ratio of the first and second current outputs.