| 摘要 |
This method is designed for calculating a quantification indicator for quantifying a dermal reaction on a skin having several chromophores. The method includes illumination of a zone to be characterized on the skin, the skin reaction being included in the zone to be characterized; and measurement of the spectrum of a back scattered radiation coming from the skin after illumination of said zone to be characterized. The method also includes determination, according to the measured spectrum, of an absorption coefficient value for the zone to be characterized, and calculation, according to the absorption coefficient value, of each chromophore concentration. The method includes calculation of the quantification indicator according to each calculated chromophore concentration. The method includes determination, according to the measured spectrum, of a diffusion coefficient value of the zone to be characterized, and the quantification indicator is further calculated according to the diffusion coefficient value. |
| 主权项 |
1. A method calculating a quantification indicator for quantifying a dermal reaction on the skin of a living being, the skin having a plurality of chromophores,
the method comprising the following steps: illuminating a zone to be characterized on the skin via an excitation light beam emitted by a source of light, the skin reaction being included in the zone to be characterized, measuring, using a spectrometer, a spectrum of a back scattered radiation coming from the skin as a result of the illumination of said zone to be characterized, determining, on the basis of the measured spectrum and for at least one given value of the wavelength of the light beam, a value of the absorption coefficient for the zone to be characterized, calculating, on the basis of the or each determined value of the absorption coefficient, a concentration of at least one chromophore in the skin, determining, on the basis of the measured spectrum and for at least one given value of the wavelength of the light beam, a value of a diffusion coefficient for the zone to be characterized, calculating the quantification indicator quantifying the dermal reaction on the basis of the previously calculated concentration of the or each chromophore, calculating the quantification indicator quantifying the dermal reaction also on the basis of the or each determined value of the diffusion coefficient, wherein the quantification indicator quantifying the dermal reaction (IND) satisfies the following equation:
IND =α+β·Ox+γ·Deox+δ·Dif+ε·Abs where IND represents the quantification indicator quantifying the dermal reaction, α, β, γ, δ, and ε are predetermined coefficients for a given value of a time period between a moment of measurement of the spectrum of a back scattered radiation and a moment of injection of the active ingredient, with β, γ and δ having non-zero values, Ox and Deox represent an oxyhaemoglobin concentration and deoxyhaemoglobin concentration, respectively, for zone to be characterized, and Dif and Abs represent an average value, respectively, of the determined value or values of the diffusion coefficient of the zone to be characterized and of the detemined values or values of the absorption coefficient of the zone to be characterized. |
