Parasiticidal oral veterinary compositions comprising systemically-acting active agents, methods and uses thereof

摘要

This invention relates to veterinary compositions for treating and/or preventing fleas or ticks infection or infestation in an animal comprising an isoxazoline active agent of Formula (II):;
or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.

主权项

1. A solid soft chewable veterinary composition effective for treating and/or preventing fleas or ticks infection or infestation in an animal comprising:
a) an isoxazoline active agent of Formula (II) at a concentration of about 5% to about 15% by weight:  or a pharmaceutically acceptable salt thereof; and b) a pharmaceutically acceptable carrier, wherein the carrier comprises a binder, a surfactant, a filler and a humectant, wherein the binder is PEG 3350; the surfactant is sodium lauryl sulfate at a concentration of about 1 to about 5% (w/w); the filler is corn starch or pre-gelatinized corn starch or a combination thereof; and the humectant is glycerol; wherein the effect is achieved at a dosage of about 10 mg/kg to about 100 mg/kg of active agent of Formula (II); and wherein the composition is effective for fleas for at least 79 days.