主权项 |
1. A pharmaceutical combination comprising an antibody specifically recognizing CD38 and at least melphalan, wherein said antibody comprises at least one heavy chain and at least one light chain, wherein said heavy chain comprises three sequential complementarity-determining regions (CDRs) having amino acid sequences represented by SEQ ID NOS: 13, 81, and 15, and wherein said light chain comprises three sequential CDRs having amino acid sequences represented by SEQ ID NOS: 16, 17, and 18, and wherein the antibody and melphalan constituents of the combination are physically separate. |