发明名称 Antitumor combinations containing antibodies recognizing specifically CD38 and melphalan
摘要 Pharmaceutical composition comprising an antibody specifically recognizing CD38 and melphalan.
申请公布号 US9259406(B2) 申请公布日期 2016.02.16
申请号 US200913130862 申请日期 2009.11.27
申请人 SANOFI 发明人 Lejeune Pascale;Vrignaud Patricia
分类号 A61K39/395;A61K31/198 主分类号 A61K39/395
代理机构 Lathrop & Gage LLP 代理人 Lathrop & Gage LLP ;Velema, Esq. James H.
主权项 1. A pharmaceutical combination comprising an antibody specifically recognizing CD38 and at least melphalan, wherein said antibody comprises at least one heavy chain and at least one light chain, wherein said heavy chain comprises three sequential complementarity-determining regions (CDRs) having amino acid sequences represented by SEQ ID NOS: 13, 81, and 15, and wherein said light chain comprises three sequential CDRs having amino acid sequences represented by SEQ ID NOS: 16, 17, and 18, and wherein the antibody and melphalan constituents of the combination are physically separate.
地址 Paris FR