发明名称 |
Methods for preparing 2,5-furandicarboxylic acid |
摘要 |
Provided are methods of producing 2,5-furandicarboxylic acid (FDCA) from renewable sources such as seaweed, alginate, oligoalginate, pectin, oligopectin, polygalacturonate, galacturonate, and/or oligogalacturonate. The sugars in the renewable sources can be converted into one or more intermediates such as 4-deoxy-L-erythro-5-hexoseulose uronate (DEHU), 4-deoxy-L-threo-5-hexosulose uronate (DTHU), 5-hydroxymethyl furfural (HMF), 2,5-dihydroxymethyl furan (DHMF), and 5-formyl-2-furancarboxylic acid (FFA), which can be converted into FDCA by dehydration and cyclization to produce 5-formyl-2-furancarboxylic acid (FFA), followed by oxidation to produce FDCA. DEHU or DTHU may also be converted into FDCA by oxidation to produce 2,3-dihydroxy-5-oxohexanedioic acid (DOHA), which then undergoes dehydration and cyclization to produce FDCA. |
申请公布号 |
US9260403(B2) |
申请公布日期 |
2016.02.16 |
申请号 |
US201414229388 |
申请日期 |
2014.03.28 |
申请人 |
BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY |
发明人 |
Yoshikuni Yasuo;Cooper Susan R.;Wargacki Adam J.;Manzer Leo E.;White James F.;Kapicak Lou;Miller Dennis J.;Peereboom Lars |
分类号 |
C07D307/68 |
主分类号 |
C07D307/68 |
代理机构 |
Marshall, Gerstein & Borun LLP |
代理人 |
Marshall, Gerstein & Borun LLP |
主权项 |
1. A method of producing 2,5-furandicarboxylic acid (FDCA), comprising:
a) providing a compound of Formula (I),b) dehydrating and cyclizing the compound of formula I into 5-formyl-2-furancarboxylic acid (FFA); and
c) oxidizing the FFA to produce FDCA. |
地址 |
East Lansing MI US |