Polymer hydrogel adhesives formed with multiple crosslinking mechanisms at physiologic pH

摘要

The present invention encompasses biocompatible reactants, biocompatible product hydrogels, methods of use thereof, and methods of synthesis thereof using a novel crosslinking mechanism between a first reactant compound including an N-Hydroxysuccinimide (NHS) ester group and a second reactant compound including a N-terminal cysteine amine group. In certain embodiments, one or more of the reactant compounds may be a macromonomer.

主权项

1. A hydrogel obtained by covalently cross-linking a first macromonomer comprising an N-Hydroxysuccinimide (NHS) ester group with a second macromonomer comprising a N-terminal cysteine group, wherein covalently cross-linking the first and second macromonomers comprises:
(a) forming an amide bond between the carboxyl carbon of the N-Hydroxysuccinimide (NHS) ester group of the first macromonomer and the primary amine of the N-terminal cysteine group of the second macromonomer to form a third macromonomer, and (b) forming a disulfide bond between primary thiol groups on two of the third macromonomers produced in step (a).