Substituted imidazopyrazines as Akt kinase inhibitors

摘要

Compounds of formula (I);
which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.

主权项

1. A compound of formula (I) in which R1 is hydrogen, hydroxy, or
a group selected from 1-6C-alkyl, 1-6C-alkoxy,
wherein said group being optionally substituted, one or more times, identically or differently, with a substituent selected from:hydroxy, halogen, 1-6C-alkyl, 1-4C-haloalkyl, 1-6C-alkoxy, —NR7R8, cyano, (═O), —C(O)NR7R8, —C(O)OR9, —NHC(O)R10, —NHS(O)2R10, heteroaryl,
wherein said substituent can be optionally substituted with 1-6C-alkoxy, R2 is hydrogen, halogen, C(O)OR9, CO(NR7R8), or
a 1-6C-alkyl group
wherein said group is optionally substituted, one or more times, identically or differently, with a substituent selected from:hydroxy, halogen, 1-6C-alkyl, 1-4C-haloalkyl, 1-6C-alkoxy, —NR7R8, cyano, —C(O)NR7R8, —C(O)OR9, —NHC(O)R10, —NHS(O)2R10, —NH-(1-6C-alkylen)-O-(1-6C-alkyl), R3 is hydrogen, 1-6C-alkyl, R4 is phenyl optionally substituted by 1-6C-alkyl, halogen, cyano, R5 is hydrogen, halogen, R6 is hydrogen, 1-6C-alkyl, X is —CH2—, Y is —CH2—, —CH(OH)—, R7, R8 which can be the same or different, is hydrogen, hydroxy, 3-7C-cycloalkyl or a group selected from 1-4C-alkyl, 1-6C-alkoxy, wherein said group is optionally substituted, one or more times, identically or differently, with a substituent selected from:
halogen, hydroxy, mono- or di-(1-4C-alkylamino), 1-4C-alkoxy, or 3-7C-cycloalkyl or, R7 and R8 together with the nitrogen to which they are attached may also form a saturated or unsaturated 3-6C-heterocyclic ring,
which is optionally substituted by (═O) R9 is hydrogen, 1-6C-alkyl, R10 is 1-4C-alkyl (optionally substituted in the same way of differently one or more times with halogen, hydroxy) or 3-7C-cycloalkyl, or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer.