Antibody molecules to oncogenic isoforms of fibroblast growth factor receptor-2 and uses thereof

摘要

Antibody molecules that specifically bind to one or more isoforms expressed and/or associated with oncogenic phenotypes in a hyperproliferative cell (e.g., a cancerous or tumor cell) are disclosed. The isoform-binding antibody molecules can be used to treat, prevent and/or diagnose cancerous conditions and/or disorders. Methods of using the isoform-binding molecules to selectively detect oncogenic isoforms, to reduce the activity and/or induce the killing of a hyperproliferative cell expressing an oncogenic isoform in vitro, ex vivo or in vivo are also disclosed. Diagnostic and/or screening methods and kits for evaluating the function or expression of an oncogenic isoform are also disclosed.

主权项

1. An antibody molecule that binds to human fibroblast growth factor receptor 2 (FGFR2) isoform IIIc or a fragment of FGFR2, said antibody molecule comprising all six complementarity determining regions (CDRs) of the light chain variable region and the heavy chain variable region of Atto-HuMab-01, wherein said CDRs of the light chain variable region comprise the amino acid sequence of SEQ ID NO:144, SEQ ID NO:145, and SEQ ID NO:146, and said CDRs of the heavy chain variable region comprise the amino acid sequence of SEQ ID NO:147, SEQ ID NO:148, and SEQ ID NO:149.