| 发明名称 | Methods and compositions for inhibiting CD32b expressing cells | ||
| 摘要 | The present invention relates to immunoglobulins that bind FcγRIIb+ cells and coengage the antigen on the cell's surface and an FcγRIIb on the cell's surface, methods for their generation, and methods for using the immunoglobulins. | ||
| 申请公布号 | US9260523(B2) | 申请公布日期 | 2016.02.16 |
| 申请号 | US201113301627 | 申请日期 | 2011.11.21 |
| 申请人 | Xencor, Inc. | 发明人 | Chu Seung Yup;Desjarlais John R.;Karki Sher Bahadur;Lazar Gregory Alan;Moore Gregory L.;Vostiar Igor |
| 分类号 | G01N33/53;C07K16/00;C07K16/28 | 主分类号 | G01N33/53 |
| 代理机构 | Polsinelli PC | 代理人 | Polsinelli PC |
| 主权项 | 1. A method of activating at least one B cell or dendritic cell comprising contacting the cell with an immunoglobulin comprising an Fc region that binds FcγRIIb on the cell surface with enhanced affinity as compared to a parent immunoglobulin and at least one Fv region that binds CD40 on the cell surface, wherein the immunoglobulin comprises Fc substitutions S267E and L328F as compared to a parent Fc region, wherein the numbering is according to the EU index, as in Kabat. | ||
| 地址 | Monrovia CA US | ||