| 发明名称 | Monophosphorylated lipid A derivatives | ||
| 摘要 | The present invention provides for monophosphorylated lipid A derivatives and carbohydrate derivatives that are useful as agents in the treatment of diseases and conditions, including cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I-IV. In addition, methods for the treatment of cancers are provided. | ||
| 申请公布号 | US9259476(B2) | 申请公布日期 | 2016.02.16 |
| 申请号 | US201414462061 | 申请日期 | 2014.08.18 |
| 申请人 | WAYNE STATE UNIVERSITY | 发明人 | Guo Zhongwu;Wang Qianli;Tang Shouchu |
| 分类号 | A61K31/70;A61K47/48;A61K39/395;A61K39/39;A61K39/00 | 主分类号 | A61K31/70 |
| 代理机构 | Brinks Gilson & Lione | 代理人 | Brinks Gilson & Lione |
| 主权项 | 1. A method of modifying cancer cells for immunotherapy comprising administering a therapeutically effective amount of a compound of formula IV: wherein R11 comprises one to two substituents each independently selected from the group consisting of: C1-C6 alkyl, —OC1-C4 alkyl, —C(O)C1-C4 alkyl, and halo; to a cancer cell. | ||
| 地址 | Detroit MI US | ||