Reactive oxidative species generating materials and methods of use

摘要

Materials capable of delivering stabilized free radicals to targeted treatment sites. The materials comprise semi-crystalline, hydrolytically degradable polymers that are subjected to ionizing radiation to create stabilized free radicals therein. Upon exposure to oxygen containing aqueous media, the materials generate reactive oxidative species which are useful in biological processes.

主权项

1. A biocompatible composite that enables generation of reactive oxidative species comprising: a first hydrolytically degradable semi-crystalline polymeric material and a second hydrolytically semi-crystalline degradable polymeric material where the first and second materials have different reactive oxidative species generation profiles,
wherein at least one of said first and second polymeric materials comprises stabilized free radicals, wherein the biocompatible composite, upon contact with aqueous media, enable multi-phasic generation of reactive oxidative species, and wherein the first polymeric material and the second polymeric material have been subjected to different doses of ionizing radiation.