Cochleate compositions directed against expression of proteins

摘要

Disclosed herein are novel siRNA-cochleate and morpholino-cochleate compositions. Also disclosed are methods of making and using siRNA-cochleate and morpholino-cochleate compositions.

主权项

1. An siRNA-cochleate composition comprising:
a cochleate; and an siRNA associated with the cochleate, wherein the cochleate comprises a negatively charged lipid component and a multivalent cation component, wherein the siRNA is complexed with a transfection agent prior to contacting a liposome, wherein the transfection agent is a cationic transfection agent.