| 发明名称 |
PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER. |
| 摘要 |
The present invention provides MDM2 inhibitor compounds of Formula (I), wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor. |
| 申请公布号 |
MX337178(B) |
申请公布日期 |
2016.02.15 |
| 申请号 |
MX20120014044 |
申请日期 |
2011.06.03 |
| 申请人 |
AMGEN INC.* |
发明人 |
MICHAEL JOHNSON;JIWEN LIU;FRANK KAYSER;XIAOQI CHEN;XUELEI YAN;ZHIHUA MA;YOSUP REW;XIANYUN JIAO;ZICE FU;JEFFREY DEIGNAN;JIASHENG FU;DAQING SUN;XIN HUANG;MING YU;FELIX GONZALEZ LOPEZ DE TURISO;SUJEN LAI;JOHN EKSTEROWICZ;BENJAMIN FISHER;DUSTIN MCMINN;JOEL MCINTOSH;XIAODONG WANG;ZHIHONG LI;MICHAEL DAVID BARTBERGER;ANA GONZÁLEZ BUENROSTRO;HILARY PLAKE BECK;RICHARD VICTOR CONNORS;JASON DUQUETTE;BRIAN MATTHEW FOX;MICHAEL WILLIAM GRIBBLE JR.;DARIN JAMES GUSTIN;JULIE ANNE HEATH;DAVID JOHN KOPECKY;YIHONG LI;JONATHAN DANTE LOW;BRIAN STUART LUCAS;LAWRENCE MCGEE;JULIO CESAR MEDINA;JEFFREY THOMAS MIHALIC;STEVEN HOWARD OLSON;PHILIP MARLEY ROVETO;YINGEAI WANG;JIANG ZHU |
| 分类号 |
C07D211/40;A61K31/4412;A61P35/00;C07D279/02;C07D401/04;C07D401/06;C07D401/12;C07D407/04;C07D407/06;C07D409/04;C07D413/06;C07D417/06;C07D471/20;C07D498/08;C07D498/20 |
主分类号 |
C07D211/40 |
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