| 摘要 |
PROBLEM TO BE SOLVED: To provide lipid particles comprising an apolipoprotein, a phosphatidylcholine and a lipid, such as a phospholipid, fatty acid or steroid lipid, associated with efflux of cholesterol from cells of the wall of blood vessels, excretion of cholesterol in liver, and the like.SOLUTION: A lipid particle comprises: an apolipoprotein A-I or a variant thereof; 1-palmitoyl-2-oleoyl-phosphatidyl choline and 1,2-dipalmitoyl-phosphatidyl choline; and a surfactant. The molar ratio of the 1-palmitoyl-2-oleoyl-phosphatidyl choline to the 1,2-dipalmitoyl-phosphatidyl choline is from 99:1 to 25:75.SELECTED DRAWING: None |
