| 摘要 |
PROBLEM TO BE SOLVED: To provide fully humanized monoclonal antibodies which have binding specificity for Toll-like receptor 2 (TLR2), and which antagonize TLR2 function, but which are essentially non-immunogenic in humans.SOLUTION: This invention relates to an isolated monoclonal antibody, or antigen binding portion thereof, which binds an epitope on human Toll-like receptor 2 with a KD of 3×10-8 M or less and which mediates Toll-like receptor 2 antagonism independently of CD32 (Fc γ receptor II), where the epitope is recognised by a reference antibody, where the reference antibody comprises a heavy chain variable region comprising a specific amino acid sequence and a light chain variable region comprising another specific amino acid sequence. Also provided are nucleic acids encoding such antibodies, as well as the use of the antibodies in medicine, in particular for the treatment of inflammatory and autoimmune diseases which are mediated by Toll-like receptor 2 activation and signalling.SELECTED DRAWING: Figure 1B |
