SYSTEMS AND METHODS FOR EVALUATING HYPERSPECTRAL IMAGING DATA USING A TWO LAYER MEDIA MODEL OF HUMAN TISSUE

摘要

The disclosure provides computer systems, non-transitory computer-readable storage medium, and methods for determining the presence of a skin indication in a subject. In some aspects the method includes acquiring a hyperspectral imaging data set from a region of interest of a human subject using a hyperspectral imager, and applying the hyperspectral imaging data set against a classifier including a two layered media model, the two layered media model including a first layer of a modeled human tissue overlying a second layer of the modeled human tissue, where the two layered media model has been trained by application of simulated data across a set of optical and geometric properties associated with the presence or the absence of a skin indication, where the two layered media model computes tissue reflectance R from the modeled human tissue by a relationship provided herein.

主权项

1. A computer implemented method, performed by a computer system having one or more processors and memory storing one or more programs for execution by the one or more processors, the method comprising:
acquiring a hyperspectral imaging data set from a region of interest of a human subject using a hyperspectral imager; and applying the hyperspectral imaging data set against a classifier comprising a two layered media model, the two layered media model comprising a first layer of a modeled human tissue overlying a second layer of the modeled human tissue, wherein the two layered media model has been trained by application of simulated data across a set of optical and geometric properties associated with the presence or the absence of a skin indication, wherein the two layered media model computes tissue reflectance R from the modeled human tissue by the relationship:R=∑i=0∞∑j=0∞exp(ω~1+jω~2)P(i,jL1)wherein,
L1 is the thickness of the first layer, {tilde over (ω)}1 is a modified single scattering of the first layer, {tilde over (ω)}2 is a modified single scattering of the second layer, exp is the exponential function, and P(i,j|L1) is a joint probability density function that a photon will experience i interactions with the first layer and j interactions with the second layer given that the first layer thickness is L1, wherein the application of the hyperspectral imaging data set against the classifier causes the classifier to produce a determination as to whether the region of interest has the skin indication.