| 主权项 |
1. A compound of Formula I:or a pharmaceutically acceptable salts thereof, wherein
R1, R2, R3, R4, R5, R6, R9, R10, R11 and R12 are independently chosen from hydrogen, hydroxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted aminocarbonyloxy, optionally substituted acyloxy, optionally substituted alkoxycarbonyloxy, and optionally substituted amino; or R1 and R2, or R5 and R6, or R7 and R8, or R9 and R10, or R11 and R12 mutually independently, together in each case denote an oxo group (═O); or R4 and R5 may optionally be joined together with any intervening atoms to form an optionally substituted heterocycloalkyl ring; R7 is chosen from hydrogen, hydroxy, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted aminocarbonyloxy, optionally substituted acyloxy, optionally substituted alkoxycarbonyloxy, and optionally substituted amino; R8 is chosen from hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, and optionally substituted alkynyl; R13 is chosen from hydrogen, optionally substituted alkyl, and formyl; R14 and R15 are joined together with any intervening atoms to form an optionally substituted 4- to 8-membered heterocycloalkyl or optionally substituted 5- to 8-membered heteroaryl ring; W1 is chosen from the following moieties: wherein Y is chosen from O and NR21; R20 is chosen from cyano, halo, hydroxy, azido, nitro, carboxy, sulfinyl, sulfanyl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted alkoxycarbonyl, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted aryloxy, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, optionally substituted carbaminodoyl, and optionally substituted alkynyl; R21 is chosen from hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, and optionally substituted heteroaryl; W2 is chosen from hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, and optionally substituted alkynyl; m is selected from 0, 1, 2, and 3; n, p, and q is independently selected from 0 and 1; and the dotted line represents a single bond or a double bond. |
