发明名称 |
INJECTABLE CONTROLLED RELEASE COMPOSITION COMPRISING HIGH VISCOSITY LIQUID CARRIER |
摘要 |
Compositions may include a pharmaceutical active agent, a high viscosity liquid carrier material (HVLCM), a lactic acid-based polymer, and an organic solvent. Related compositions and methods are also disclosed. For instance, a carrier formulation for controlled release of injectable drugs is disclosed. The formulation may include a non-water soluble high viscosity liquid which may be sucrose acetate isobutyrate, a lactic-acid based polymer which may be a poly(lactic acid)(glycolic acid), and an organic solvent which maintains the composition in a monophasic form at 25° C. in one atmosphere. Drug in the formulation may be released upon administration such that less than 10% (e.g. 2-8%) of drug is released in the first 5 hours; 10% to 80% of the drug is released during a period of 5 hours to 7 days after administration; and 10% to 40% of the drug is released gradually over a period of 7 days to 28 days from initial administration. The drug may be an anti-schizophrenia agent delivered by injection. |
申请公布号 |
US2016038596(A1) |
申请公布日期 |
2016.02.11 |
申请号 |
US201414773642 |
申请日期 |
2014.03.11 |
申请人 |
DURECT CORPORATION ;ZOGENIX, INC. |
发明人 |
WRIGHT Jeremy C.;TAMRAZ Wilma;LEONARD John J.;GIBSON John W.;BRANHAM Keith E.;SJOBECK Stefania;Boyd Brooks;RUBINO Christopher M. |
分类号 |
A61K47/22;A61K47/26;A61M5/20;A61M5/24;A61M5/30;A61M5/315;A61K31/519;A61K47/20 |
主分类号 |
A61K47/22 |
代理机构 |
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代理人 |
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主权项 |
1. A composition comprising:
a pharmaceutical active agent; 25 wt % to 80 wt %, based on total weight of the composition, of a non-polymeric, non-water soluble high viscosity liquid carrier material (HVLCM) having a viscosity of at least 5000 cP at 37° C. that does not crystallize neat at 25° C. and 1 atmosphere; a lactic acid-based polymer comprising an alkoxy end group; and an organic solvent. |
地址 |
Cupertino CA US |