发明名称 |
DOSAGE AND ADMINISTRATION FOR PREVENTING CARDIOTOXICITY IN TREATMENT WITH ERBB2-TARGETED IMMUNOLIPOSOMES COMPRISING ANTHRACYCLINE CHEMOTHERAPEUTIC AGENTS |
摘要 |
Methods for determining dosage of HER2-targeted anthracycline-containing immunoliposomes are disclosed, as are methods of treating cancer patients with HER2-positive tumors using dosages so determined. Upon administration, the dosages share the low cardiotoxicity profile of standard dosages of non-immunoliposomal (untargeted), anthracycline-containing liposomes. |
申请公布号 |
US2016038416(A1) |
申请公布日期 |
2016.02.11 |
申请号 |
US201514831199 |
申请日期 |
2015.08.20 |
申请人 |
MERRIMACK PHARMACEUTICALS, INC. |
发明人 |
REYNOLDS JOSEPH G.;OLIVIER, JR. KENNETH J.;HENDRIKS BART S.;WICKHAM THOMAS;KLINZ STEPHAN;GERETTI ELENA |
分类号 |
A61K9/127;A61K9/00;A61K31/704 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
CAMBRIDGE MA US |