发明名称 |
METHOD OF ISOLATING INGENOL |
摘要 |
The present invention relates to a new method for isolating ingenol (C20H28O5) from mixtures of diterpenoid esters and ingenol esters in a single step. Ingenol isolated by means of this method can be used as a precursor for the synthesis of biologically active ingenol derivatives, such as ingenol-3-angelate and ingenol-3-tigliate. |
申请公布号 |
US2016039733(A1) |
申请公布日期 |
2016.02.11 |
申请号 |
US201514922581 |
申请日期 |
2015.10.26 |
申请人 |
INDENA S.P.A. |
发明人 |
Bellido Cabello De Alba Maria Luz;Appendino Giovanni;Pagani Alberto;Munoz Blanco Eduardo |
分类号 |
C07C45/85;C07D319/08;B01D15/08;C07C67/08 |
主分类号 |
C07C45/85 |
代理机构 |
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代理人 |
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主权项 |
1. A method of isolating ingenol from plant material, said method comprising:
a) subjecting said plant material to mechanical stirring in a solution of sodium methylate in methanol to obtain a solution containing hydrolyzed ingenol; b) extracting from the preceding solution a fraction containing ingenol with an acidified water and an organic solvent solution to obtain a fraction contain ingenol; and c) optionally purifying the ingenol to provide an isolated ingenol. |
地址 |
Milano IT |