PEPTIDES HAVING ACTIVITIES FOR STIMULATING BONE DIFFERENTIATION AND ACTIVITY OF HUMAN PERIODONTAL LIGAMENT FIBROBLAST AND USES THEREOF

摘要

A peptide which is composed of amino acid sequences from a first sequence of a sequence listing or a second sequence of the sequence listing in the present invention expresses efficacy for stimulating proliferation and differentiation of osteoblasts and for stimulating proliferation and activation of periodontal ligament fibroblasts. The peptide in the present invention increases BMP signaling such as smad1/5/8 phosphorylation and ultimately expresses activation of osteoblasts by increasing growth of osteoblasts and expression of differentiation markers such as COL1A1, BSP, and ALP. The peptide in the present invention stimulates growth of periodontal ligament fibroblasts through PI3K and Akt phosphorylation and ultimately expresses activation of periodontal tissue regeneration by increasing expression of activation markers such as COL1A1 and DSPP. Provided are a composition comprising the peptides described in the present invention for preventing or treating bone diseases and a composition for preventing or treating periodontal diseases.