| 发明名称 |
MATERIALS AND METHODS FOR TREATMENT OF LIVER CANCER |
| 摘要 |
Granulin-epithelin precursor (GEP), a pluripotent growth factor, is a hepatic oncofetal protein defining a cancer stem cell (CSC) population in liver cancer. The present invention provides the use of GEP inhibitors (including anti-GEP antibody) for inhibiting immune evasion by liver cancer cells and for eliminating liver cancer stem cells. |
| 申请公布号 |
US2016039923(A1) |
申请公布日期 |
2016.02.11 |
| 申请号 |
US201514922926 |
申请日期 |
2015.10.26 |
| 申请人 |
The University of Hong Kong |
发明人 |
Cheung Siu Tim;Fan Sheung-Tat;Cheung Phyllis Fung Yi |
| 分类号 |
C07K16/22;A61K35/17;A61K45/06;A61K39/395 |
主分类号 |
C07K16/22 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of promoting natural killer (NK) cell activity, comprising administering to a subject in which enhanced NK cell activity is desired an effective amount of an anti-GEP antibody that promotes natural killer (NK) cell activity. |
| 地址 |
Hong Kong CN |
