发明名称 |
MONOCLONAL ANTIBODY FOR ANTAGONIZING AND INHIBITING BINDING OF VASCULAR ENDOTHELIAL CELL GROWTH FACTOR AND ITS RECEPTOR, AND CODING SEQUENCE AND USE THEREOF |
摘要 |
A mouse monoclonal antibody for antagonizing and inhibiting binding of a vascular endothelial cell growth factor (VEGF) and its receptor (VEGF-R), and a heavy chain variable region and light chain variable region amino acid sequence thereof. Also disclosed are a humanized preparation process of the antibody and a heavy chain variable region and light chain variable region amino acid sequence of the humanized antibody. The humanized antibody or its derivative can act as an ingredient of a pharmaceutical composition or be prepared into a suitable pharmaceutical preparation, is administered alone or in combination with a chemotherapy drug or other treatment means, and is used in broad-spectrum treatment of various solid tumors such as colon cancer, breast cancer and rhabdomyosarcoma. |
申请公布号 |
US2016039921(A1) |
申请公布日期 |
2016.02.11 |
申请号 |
US201314651785 |
申请日期 |
2013.11.05 |
申请人 |
SUZHOU STAINWEI BIOTECH INC. |
发明人 |
Luo Shiping;Hu Hongqun;Chen Zui;Cai Mingwen;Sun Yanan;Liu Haiyun;Zhou Jianying;Song Xiaoqi;Ping Xiaoya;Chen Siyu;Shi Donghong;Xu Yiqing;Zhou Qunmin |
分类号 |
C07K16/22 |
主分类号 |
C07K16/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Jiangsu CN |