Compositions with Thixotropy and Enhanced Dissolution Reproducibility and Stability

摘要

The present disclosure provides extended release compositions including, formulations that comprise such compositions, which exhibit desirable dissolution of an active agent while maintaining its physical stability in a dosage form including, for example, providing reduced sample variability, e.g., in the form of reduced inter-capsule variability and/or a reduction in storage-time dependent change in mean release of the active agent from the composition. Related methods of making and administering the disclosed compositions and formulations are also provided.

主权项

1. A composition comprising:
an opioid; about 15% by weight to about 45% by weight, based on total weight of the composition, of a solvent; about 1% by weight to about 20% by weight, based on total weight of the composition, of a rheology modifier; a mineral particle; and about 1% to about 2.5% by weight, based on total weight of the composition, of water.