发明名称 PHENAZINE-3-ONE AND PHENOTHIAZINE-3-ONE DERIVATIVES FOR TREATMENT OF OXIDATIVE STRESS DISORDERS
摘要 Disclosed herein are phenazine-3-one and phenothiazine-3-one derivative compounds and methods of using such compounds for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging.
申请公布号 US2016039776(A1) 申请公布日期 2016.02.11
申请号 US201414776688 申请日期 2014.03.14
申请人 EDISON PHARMACEUTICALS, INC. 发明人 HINMAN Andrew W.;DAVIS Dana;SHRADER William D.
分类号 C07D279/20 主分类号 C07D279/20
代理机构 代理人
主权项 1. A compound of formula (I): wherein: R1 and R2 are independently selected from the group consisting of: —C1-C4 alkyl, —O—C1-C4 alkyl, —H, and —C1-C4 haloalkyl, and R3 is selected from the group consisting of: —C1-C12 alkyl, —H, —O—C1-C12 alkyl, and —C1-C12 haloalkyl; or R1 and R2 are both —CH3 or R1 and R2 are both —OCH3, and R3 is selected from the group consisting of: n is 0, 1, 2, 3, or 4; R4, R5, R6, and R7 are independently selected from the group consisting of: —C1-C12 haloalkyl, —C(O)—N(R13)(R14), —C1-C12 alkyl, —H, —OH, —C2-C12 alkenyl, —O—C1-C12 alkyl, —O—C(O)—C1-C12 alkyl, —O—C1-C12 haloalkyl, —C6-C10 aryl, —O—C6-C10 aryl, —C1-C6 alkyl-C6-C10 aryl, —O—C1-C6 alkyl-C6-C10 aryl, —N—(R8)(R9), —C(O)—O—C1-C12 alkyl, —S(O)2—C1-C12 alkyl, with the proviso that at least two of R4, R5, R6, and R7 are independently selected from the group consisting of: —H and —CH3; R8 and R9 are independently —H or —C1-C12 alkyl; R13 is —H or —C1-C4 alkyl; R14 is —C1-C12 alkyl optionally substituted with hydroxy, —O—C1-C4, heterocyclyl, aryl, or heteroaryl, or wherein R14 is —C1-C15 alkyl wherein two or more of the carbons in the alkyl group have been replaced by oxygen; m is 0, 1, 2, or 3; and R11 is S or NH; or a stereoisomer, mixture of stereoisomers, solvate, hydrate, or pharmaceutically acceptable salt thereof; with the proviso that the compound is not: or a stereoisomer, mixture of stereoisomers, solvate, hydrate, or pharmaceutically acceptable salt thereof.
地址 Mountain View CA US