| 主权项 |
1. A compound of Formula I, or a pharmaceutically acceptable salt thereof, wherein: R1 is chosen from —C(O)NH(OH) and —N(OH)C(O)R4; R2 is aryl, heteroaryl, and heterocycloalkyl, each of which is optionally substituted with 1 to 3 substituents independently chosen from halo, alkyl, cycloalkyl, haloalkyl, hydroxyl, alkoxy, and nitrile; X is absent or X is chosen from —O—, —NR6—, and —[C(R7R8)]p—; R3 is chosen from hydrogen, alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aralkyl, and heteroaralkyl, each of which is optionally substituted with 1 to 3 substituents independently chosen from halo, —CONRbRc, alkyl, alkyl substituted with —NRbRc, cycloalkyl, haloalkyl, hydroxyl, alkoxy, haloalkoxy, alkoxy substituted with —NRbRc, aryl, heteroaryl, and nitrile; R4 is chosen from hydrogen, lower alkyl and lower haloalkyl; for each occurrence, R5 is independently chosen from halo, lower alkyl, lower haloalkyl, and hydroxyl; or R3 taken together with R5, and any intervening atoms, forms a 3- to 7-membered heterocycloalkyl or cycloalkyl ring; m and m′ are independently chosen from 1, 2, and 3, provided that m+m′≦4; n is chosen from 0, 1, 2 and 3; p is chosen from 1 and 2; R6 is chosen from hydrogen, lower alkyl, cycloalkyl, and lower haloalkyl; and for each occurrence, R7 and R8 are each independently chosen from hydrogen, halo, lower alkyl, and lower haloalkyl, Rb is chosen from H, C1-C6 alkyl, aryl, and heteroaryl; and Rc is chosen from hydrogen and C1-C4 alkyl; or Rb and Rc, and the nitrogen to which they are attached, form a heterocycloalkyl group; and where for Rb and Rc, each C1-C6 alkyl, cycloalkyl, aryl, heterocycloalkyl, and heteroaryl is unsubstituted or substituted with one or more substituents independently selected from C1-C4 alkyl, C3-C6 cycloalkyl, aryl, heteroaryl, aryl-C1-C4 alkyl-, heteroaryl-C1-C4 alkyl-, C1-C4 haloalkyl-, —OC1-C4 alkyl, —OC1-C4 alkylphenyl, —C1-C4 alkyl-OH, —C1-C4 alkyl-O—C1-C4 alkyl, —OC1-C4 haloalkyl, halo, —OH, —NH2, —C1-C4 alkyl-NH2, —N(C1-C4 alkyl)(C1-C4 alkyl), —NH(C1-C4 alkyl), —N(C1-C4 alkyl)(C1-C4 alkylphenyl), —NH(C1-C4 alkylphenyl), cyano, nitro, oxo (as a substitutent for heteroaryl), —CO2H, —C(O)OC1-C4 alkyl, —CON(C1-C4 alkyl)(C1-C4 alkyl), —CONH(C1-C4 alkyl), —CONH2, —NHC(O)(C1-C4 alkyl), —NHC(O)(phenyl), —N(C1-C4 alkyl)C(O)(C1-C4 alkyl), —N(C1-C4 alkyl)C(O)(phenyl), —C(O)C1-C4 alkyl, —C(O)C1-C4 phenyl, —C(O)C1-C4 haloalkyl, —OC(O)C1-C4 alkyl, —SO2(C1-C4 alkyl), —SO2(phenyl), —SO2(C1-C4 haloalkyl), —SO2NH2, —SO2NH(C1-C4 alkyl), —SO2NH(phenyl), —NHSO2(C1-C4 alkyl), —NHSO2(phenyl), and —NHSO2(C1-C4 haloalkyl). |
