USE OF BUPRENORPHINE DIMER IN THE TREATMENT OF PERIPHERAL NEUROPATHIC PAIN

摘要

The present invention provides method and compositions for the treatment of peripheral neuropathic pain by administering to a patient a therapeutically effective amount of a buprenorphine dimer compound, wherein the two buprenorphine portions are linked via an ethylene spacer, and wherein the spacer is bonded to the two opioid molecules via an ether bond. Preferably, the active agent is provided in the form of an injectable depot.

主权项

1. A method of treating a patient suffering from peripheral neuropathic pain which comprises parenterally administering to said patient a therapeutically effective dose of a pharmaceutical composition comprising a pharmaceutically acceptable carrier or excipient and buprenorphine dimer compound having Formula (I):or a pharmaceutically acceptable salt or solvate thereof.