Two-Dimensional Semi-LASER Correlation Spectroscopy with Well-Maintained Cross Peaks

摘要

A sLASER-first-COSY sequence is disclosed. After a delay time, Δ1, from application of a first 90° radio frequency (RF) pulse, a first pair of adiabatic full-passage (AFP) pulses are applied to an object in a MRI scanner. The first 90° RF pulse is a non-adiabatic slice-selective 90° RF pulse and the first pair of AFP pulses is separated by an inter-pulse time interval, Δ2. A second pair of AFP pulses, separated by the time Δ2, is then applied, followed by a second 90° RF pulse. The second 90° RF pulse is a non-adiabatic non-slice-selective 90° RF pulse. MR signal is acquired after an echo time (TE) from application of the excitation RF pulse. The present method may achieve intended full magnetization transfer between a coupled spin pair of a metabolite and maintain metabolite cross peak intensity of a coupled spin pair of a metabolite in the object.

主权项

1. In a magnetic resonance imaging (MRI) scanner system, a computer-implemented method comprising:
applying to an object in the MRI scanner system a first 90° radio frequency (RF) pulse, wherein the first 90° RF pulse is a non-adiabatic slice-selective 90° RF pulse; after a delay time, Δ1, from application of the first 90° RF pulse, applying to the object, a first pair of adiabatic full-passage (AFP) pulses, wherein the first pair of AFP pulses is separated by an inter-pulse time interval, Δ2; applying to the object, a second pair of AFP pulses, wherein the second pair of AFP pulses is separated by the time Δ2; applying to the object a second 90° RF pulse, wherein the second 90° RF pulse is a non-adiabatic non-slice-selective 90° RF pulse; and acquiring magnetic resonance (MR) signal after an echo time (TE) from application of the excitation RF pulse.