ANTIBODIES SPECIFIC TO CADHERIN-17

摘要

The present disclosure provides antibodies, including isolated monoclonal antibodies, which specifically bind to Cadherin-17 with high affinity. Nucleic acid molecules encoding Cadherin-17 antibodies, expression vectors, host cells and methods for expressing the Cadherin-17 antibodies are also provided. Bispecific molecules and pharmaceutical compositions comprising the Cadherin-17 antibodies are also provided. Methods for detecting Cadherin-17, as well as methods for treating various cancers, including colorectal cancer, are disclosed.

主权项

1. An isolated anti-Cadherin-17 antibody comprising a heavy chain variable region CDR1 comprising SEQ ID NO: 1, a heavy chain variable region CDR2 comprising SEQ ID NO: 5, a heavy chain variable region CDR3 comprising SEQ ID NO: 14, a light chain variable region CDR1 comprising SEQ ID NO: 22, a light chain variable region CDR2 comprising SEQ ID NO: 28, and a light chain variable region CDR3 comprising SEQ ID NO: 32.