| 发明名称 |
Metapneumovirus Immunogens and Related Materials and Methods |
| 摘要 |
The present invention provides compositions useful to induce immune response to human metapneumovirus. Also provided are related materials and methods, including methods to induce an immune response in a mammal, comprising administering the compositions herein. |
| 申请公布号 |
US2016039884(A1) |
申请公布日期 |
2016.02.11 |
| 申请号 |
US201414777095 |
申请日期 |
2014.03.14 |
| 申请人 |
OHIO STATE INNOVATION FOUNDATION ;RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL |
发明人 |
Li Jianrong;Wei Yongwei;Zhang Yu;Peeples Mark E. |
| 分类号 |
C07K14/005;C12N7/00 |
主分类号 |
C07K14/005 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A composition comprising a nucleic acid molecule encoding a human metapneumovirus (hMPV) having a mutated integrin-binding motif (RGD motif) in a fusion (F) protein of hMPV, wherein the RGD motif is mutated as compared to wildtype hMPV. |
| 地址 |
Columbus OH US |
