Selective Estrogen Receptor Modulators With Short Half-Lives and Uses Thereof

摘要

The present invention relates to the long-term administration of a selective estrogen receptor modulator (SERM) with a short half-life for the treatment of a variety of estrogen receptor-mediated conditions. The SERM may be administered at a concentration at or below that of a SERM with a long half-life in order to achieve an equivalent therapeutic effect.

主权项

1. A method for treating an estrogen receptor-mediated condition comprising administering a selective estrogen receptor modulator (SERM) or a pharmaceutically acceptable salt thereof having a half-life of 30 hours or less for a period of at least 6 months at a dosage of between 1 and 19 mg to a patient in need of such treatment, with the proviso that said SERM is other than trans-clomiphene.