| 发明名称 |
METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION |
| 摘要 |
This invention relates to methods and compositions for treating cognitive impairment associated with central nervous system (CNS) disorders. In particular, it relates to the use of inhibitors of synaptic vesicle glycoprotein 2A (SV2A), alone or in combination with valproate, in treating cognitive impairment associated with central nervous system (CNS) disorders in a subject in need or at risk thereof, including, without limitation, subjects having or at risk for age-related cognitive impairment. |
| 申请公布号 |
US2016038463(A1) |
申请公布日期 |
2016.02.11 |
| 申请号 |
US201414776576 |
申请日期 |
2014.03.14 |
| 申请人 |
THE JOHNS HOPKINS UNIVERSITY |
发明人 |
Gallagher Michela;Haberman Rebecca;Koh Ming Teng;Bakker Arnold |
| 分类号 |
A61K31/4015;C12Q1/68;G09B3/06;G01N33/74;A61B5/00;A61K31/19;G01N33/68 |
主分类号 |
A61K31/4015 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for treating cognitive impairment associated with a central nervous system (CNS) disorder in a subject in need or at risk thereof, delaying or slowing the progression of cognitive impairment, or reducing the rate of decline of cognitive function in the subject, the method comprising the step of administering to said subject a therapeutically effective amount of a synaptic vesicle protein 2A (SV2A) inhibitor or a pharmaceutically acceptable salt, hydrate, solvate, polymorph, or prodrug thereof. |
| 地址 |
Baltimore MD US |
