LIPOPROTEIN LIPASE ACTIVATOR FOR MITIGATION OF ATHEROSCLEROSIS AND METHODS OF USING SAME

摘要

Provided herein are methods of increasing LPL activity or ANGTPL4 inhibition of LPL; activating LPL; treating, preventing, or ameliorating atherosclerosis; treating hypertriglyceridemia; and improving lipid profile. The methods involve the use of a carboxamide having a general formula of R1ONHR2, wherein R1 comprises a cyclopropane ring, and R2 comprises one of an imidazole ring or a morpholine ring. Also provided is a pharmaceutical composition having a carboxamide with a general formula of R1ONHR2, wherein R1 comprises a cyclopropane ring, and R2 comprises one of an imidazole ring or a morpholine ring.