发明名称 |
Stabilization of immunoglobulins through aqueous formulation with histidine at weak acidic to neutral pH |
摘要 |
The present invention provides, among other aspects, storage stabile aqueous formulations of immunoglobulins with histidine at a mildly acidic to neutral pH. The present invention also provides methods for stabilizing immunoglobulin compositions by formulating with histidine at a mildly acidic to neutral pH. Advantageously, the methods and formulations provided herein allow stabile aqueous compositions of immunoglobulins at mildly acidic to neutral pH useful for parenteral administration. |
申请公布号 |
AU2011301807(C1) |
申请公布日期 |
2016.02.11 |
申请号 |
AU20110301807 |
申请日期 |
2011.09.16 |
申请人 |
BAXALTA GMBH;BAXALTA INCORPORATED |
发明人 |
BUTTERWECK, HARALD ARNO;KOELBL, BERNHARD;HOFBAUER, LUCIA;TESCHNER, WOLFGANG;SCHWARZ, HANS-PETER |
分类号 |
A61K38/00;A61K9/00;A61K38/48;A61K39/395;A61K47/02;A61K47/12;A61K47/18 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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