| 摘要 |
The present invention provides a method for preparing intermediates of Himbacine analogs. The method provided by the present invention comprises: performing Suzuki reaction between 5-halo-2-hydroxymethyl pyridine and phenylboronic acid esters, reacting the coupling product with halogenating agents, then reacting with phosphite esters and obtaining the target compound, {[5-(3-fluorophenyl)pyridine-2-yl]alkyl} dialkyl phosphonate. The method provided by the present invention has the advantages of simple operation, high yield, and safe and easily available raw materials. |
