发明名称 ORAL FORMULATIONS OF MITOCHONDRIALLY-TARGETED ANTIOXIDANTS AND THEIR PREPARATION AND USE
摘要 Provided are stable liquid and solid formulations of oxidized and reduced mitochondria-targeted antioxidants, and methods of their preparation and use.
申请公布号 US2016038603(A1) 申请公布日期 2016.02.11
申请号 US201514887406 申请日期 2015.10.20
申请人 MITOTECH SA 发明人 Skulachev Maxim V.;Skulachev Vladimir P.;Zamyatnin Audrey A.;Tashlitsky Vadim N.;Zinovkin Roman A.;Egorov Maxim V.;Friedhoff Lawrence T.;Pletushkina Olga Y.;Andreev-Andrievsky Alexander A.;Zinevich Tatiana V.
分类号 A61K47/48;A61K47/12;A61K47/10;A61K31/122;A61K31/047 主分类号 A61K47/48
代理机构 代理人
主权项 1. A method of treating dermal wounds, comprising orally administering to a patient in need thereof a therapeutically effective amount of a formulation comprising a compound of Formula I, in liquid or solid form: wherein: A is an antioxidant of Formula II: and/or reduced form thereof, wherein: m comprises an integer from 1 to 3;Y is methyl;L is a linker group, comprising a straight or branched hydrocarbon chain optionally substituted by one or more double or triple bond, or ether bond, or ester bond, or C—S, or S—S, or peptide bond; and which is optionally substituted by one or more substituents selected from alkyl, alkoxy, halogen, keto group, amino group;n is an integer from 1 to 20; andB is a targeting group is: a Skulachev ion Sk+ Z−, wherein: Sk is a lipophilic cation or a lipophilic metalloporphyrin; andZ is a pharmaceutically acceptable anion.
地址 Luxembourg LU