发明名称 |
THERAPEUTIC ACID CERAMIDASE COMPOSITIONS AND METHODS OF MAKING AND USING THEM |
摘要 |
The present invention relates to a therapeutic composition including a ceramidase mixture and a pharmaceutically acceptable carrier, where the ceramidase mixture includes an inactive acid ceramidase precursor and an active acid ceramidase. The invention also relates to a method of acid ceramidase treatment, including formulating the acid ceramidase used in said treatment as a ceramidase mixture, where the ceramidase mixture includes an inactive acid ceramidase precursor and an active acid ceramidase. The invention further relates to a method of producing a therapeutic composition including providing a medium containing an inactive acid ceramidase precursor; incubating the medium under conditions effective to transform a portion of the inactive acid ceramidase precursor to active acid ceramidase; and recovering the incubated medium as a ceramidase mixture comprising the inactive acid ceramidase precursor and an active acid ceramidase. The present invention also relates to preparation of a therapeutic composition of a ceramidase lacking acid sphingomyelinase. |
申请公布号 |
US2016038574(A1) |
申请公布日期 |
2016.02.11 |
申请号 |
US201414776442 |
申请日期 |
2014.03.13 |
申请人 |
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI |
发明人 |
SCHUCHMAN Edward H. |
分类号 |
A61K38/50;C12N9/80;A61K45/06 |
主分类号 |
A61K38/50 |
代理机构 |
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代理人 |
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主权项 |
1. A method of producing a therapeutic composition, the method comprising:
providing a medium containing an inactive acid ceramidase precursor; incubating the medium under conditions effective to transform a portion of the inactive acid ceramidase precursor to active acid ceramidase; and recovering the incubated medium as a ceramidase mixture comprising the inactive acid ceramidase precursor and an active acid ceramidase. |
地址 |
New York NY US |