| 摘要 |
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date W O 2013/138617 A1 19 September 2013 (19.09.2013) W I P 0 I P C T (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C07D 403/12 (2006.01) C07D 409/14 (2006.01) kind of national protection available): AE, AG, AL, AM, C07D 231/38 (2006.01) C07D 417/12 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, C07D 401/12 (2006.01) A61K31/36 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, C07D 405/12 (2006.01) A61P 11/00 (2006.01) DO, DZ, EC, EE, EG, ES, Fl, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, (21) International Application Number: KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, PCT/US2013/031473 ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, (22) International Filing Date: NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, 14 March 2013 (14.03.2013) RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, (25) Filing Language: English ZM, Zw. (26) Publication Language: English (84) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of regional protection available): ARIPO (BW, GH, 61/612,007 16 March 2012 (16.03.2012) US GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (71) Applicant: AXIKIN PHARMACEUTICALS, INC. TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, [US/US]; 10835 Road To The Cure, Suite 250, San Diego, EE, ES, Fl, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, CA 92121 (US). MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (72) Inventors: RAAUM, Erik, Dean; 10835 Road To The TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, Cure, Suite 200, San Diego, CA 92121 (US). POTTER, ML, MR, NE, SN, TD, TG). Garrett, Thomas; 10835 Road To The Cure, Suite 250, Published: San Diego, CA 92121 (US). LY, Tai, Wei; 10824 Cam- _ with international search report (Art. 21(3)) inito Colorado, San Diego, CA 92131 (US). (74) Agents: CORUZZI, Laura, A. et al.; Jones Day, 222 East S 41st Street, New York, NY 10017-6702 (US). (54) Title: 3,5-DIAMINOPYRAZOLE KINASE INHIBITORS = R5 = R4 NR'(IA) (57) Abstract: Provided herein are 3,5-diaminopyrazoles, for example, compounds of the following Formula (IA), that are useful for 0 modulating regulated-in-COPD kinase activity, and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a RC kinase-mediated disorder, disease, or condition. |
