COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING CORONARY HEART DISEASE

摘要

The invention pertains to a method of determining a statin dosage for an individual in need of treatment with a statin, comprising determining a SLCO1B1 genotype from a nucleic acid sample of the individual, said genotype comprising the presence or absence of the SLCO1B1-056 polymorphism, and determining an ApoE genotype or phenotype identifying an ApoE polymorphism selected from the group consisting of ApoE2, ApoE3, ApoE4, and any combination thereof, wherein the combination of a SLCO1B1 genotype identifying the presence of the SLCO1B1-056 C polymorphism and the ApoE genotype or phenotype identifying one of the ApoE3/4 or ApoE4/4 genotypes indicates the statin dosage.

主权项

1. A method of determining a statin dosage, the method comprising the steps of:
conducting an assay in a biological sample to identify the presence or absence of a SLCO1B1 biomarker and an Apolipoprotein E gene (ApoE) biomarker that are associated with statin efficacy; and determining a dosage of statin for the individual based upon the presence or absence of the SLCO1B1 and ApoE biomarkers, wherein the statin is selected from the group consisting of pravastatin, atorvastatin, and cerivastatin.