Immunoglobulin Fc conjugate maintaining FcRn binding strength

摘要

The present invention relates to a physiologically active polypeptide - immunoglobulin Fc fragment conjugate in which a physiologically active polypeptide is linked to an immunoglobulin Fc fragment including an FcRn binding region via a non-peptide linker, wherein the conjugate maintains the inherent binding strength of the immunoglobulin Fc fragment; a method for manufacturing the conjugate; a method for maintaining the inherent binding force of the conjugate to FcRn; and a composition comprising the conjugate and maintaining the inherent binding strength of the immunoglobulin Fc fragment to FcRn.